Acetyl Tetrapeptide-5 is a man-made four-amino-acid peptide frequently used in eye-area cosmetics. It's included to calm and reduce the look of under-eye puffiness and shadows, though the supporting research is only fair in quality.
Used around the eyes to calm puffiness and dark circles.
Category
Soothing, Anti-aging, Skin Conditioning
Type
Peptide
Ratings
Overall Rating
Fair
Comedogenic Risk
None
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Acetyl Tetrapeptide-5 a Good Ingredient?
It rates Fair because benefits for under-eye puffiness rely largely on supplier studies, with modest, temporary effects. A small risk of irritation exists if product migrates into the eyes or on very delicate skin.
What it does
Skin Benefits
Can provide a soothing feel and diminish the look of morning puffiness around the eyes. Evidence is limited, so results vary and are often mild.
Where you'll find it
Uses in Skincare & Cosmetics
Common in eye gels, roll-on eye serums, and under-eye sheet patches for quick refresh. Also appears in lightweight daytime eye creams.
Before you use it
Safety
Generally well tolerated for eye-area use, though transient stinging or redness can occur if it enters the eyes or on sensitive skin. No widely recognized regulatory restrictions at typical levels.