Arginine/Lysine Polypeptide

This lab-created polypeptide is built from arginine and lysine amino acid residues. Leave-on skincare uses it to support a firmer, smoother feel and boost surface texture, though peer-reviewed evidence is moderate and outcomes vary with formula and routine.
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Snapshot

Overview
A peptide that supports firmer, smoother-looking skin over time.
Category
Anti-aging, Firming, Tone/Texture
Type
Peptide

Ratings

Overall Rating

Fair

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Arginine/Lysine Polypeptide a Good Ingredient?

That puts it at Fair: proposed to promote a firmer, smoother look, but clinical backing is limited and effects can be subtle. Mild irritation or sensitization may occur, particularly near the eye area.

Skin Benefits

Supports a springier feel and a more refined surface appearance. Visible effects are often subtle and require consistent use.

Uses in Skincare & Cosmetics

Common in firming serums, eye creams, and leave-on treatments, and sometimes incorporated into sheet masks for a quick boost.

Safety

Generally low risk, though peptides can occasionally trigger mild irritation or redness; patch testing is prudent for sensitive skin. Avoid getting product into the eyes and discontinue if irritation persists.