Glutathione

Glutathione is a cellular tripeptide (glutamate, cysteine, glycine) used in skincare as an antioxidant. Topically it's included for tone-evening and radiance support, but stability and skin-penetration challenges mean visible results are inconsistent.
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Snapshot

Overview
A cellular antioxidant that may help even out tone and add radiance.
Category
Antioxidant, Brightening, Hyperpigmentation
Type
Antioxidant

Ratings

Overall Rating

Fair

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Glutathione a Good Ingredient?

It's Fair because, while it's biologically relevant, topical instability and limited penetration hold back consistent, noticeable outcomes. Irritation is generally low, though sensitive users may experience mild reactions, which is enough to keep it out of Good.

Skin Benefits

Provides antioxidant support that can reduce the look of dullness and uneven tone. Works best as part of an antioxidant blend rather than a standalone brightener.

Uses in Skincare & Cosmetics

Common in serums, essences, and sheet masks targeting radiance. Often paired with vitamins C/E or niacinamide in moisturizers.

Safety

Usually well tolerated; patch test if reactive. No known photosensitizing or comedogenic concerns at typical cosmetic levels.