Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1

Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1 is a biotechnology-derived signaling peptide produced via plant expression systems, used to promote smoother, firmer-looking skin, though peer-reviewed clinical data for topicals are limited.
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Snapshot

Overview
A lab-made peptide aimed at smoother, firmer-looking skin.
Category
Anti-aging, Tone/Texture, Firming, Skin Conditioning
Type
Peptide

Ratings

Overall Rating

Fair

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 a Good Ingredient?

This is promising peptide technology, yet human clinical support for topical efficacy is limited, which is why it rates Fair; the benefits are likely modest and formula-dependent, with some sensitivity possible.

Skin Benefits

May refine surface texture and lend a temporarily plumped appearance, though current human evidence remains limited, so outcomes vary; best seen as a supporting anti-aging component.

Uses in Skincare & Cosmetics

Formulated into targeted serums, eye creams, and sheet masks within anti-aging routines, and occasionally into lightweight moisturizers.

Safety

Generally low irritation potential, though peptides can still trigger sensitivity in some users. Patch test first and discontinue if irritation develops.