Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1 is a biotechnology-derived signaling peptide produced via plant expression systems, used to promote smoother, firmer-looking skin, though peer-reviewed clinical data for topicals are limited.
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 a Good Ingredient?
This is promising peptide technology, yet human clinical support for topical efficacy is limited, which is why it rates Fair; the benefits are likely modest and formula-dependent, with some sensitivity possible.
What it does
Skin Benefits
May refine surface texture and lend a temporarily plumped appearance, though current human evidence remains limited, so outcomes vary; best seen as a supporting anti-aging component.
Where you'll find it
Uses in Skincare & Cosmetics
Formulated into targeted serums, eye creams, and sheet masks within anti-aging routines, and occasionally into lightweight moisturizers.
Before you use it
Safety
Generally low irritation potential, though peptides can still trigger sensitivity in some users. Patch test first and discontinue if irritation develops.
Products with Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1