Palmitoyl tripeptide-38 is a modified signaling peptide with a palmitic anchor that improves its affinity for skin. Leave-on care includes it to promote smoother-looking texture and a sense of increased firmness with regular use.
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Palmitoyl Tripeptide-38 a Good Ingredient?
Rated Good because small in-vivo studies, often supplier-run, suggest visible wrinkle-smoothing, and its palmitoylated form improves stability and skin compatibility with a low irritation profile. It doesn't go higher because the supporting studies are mostly small and industry-sponsored rather than independent.
What it does
Skin Benefits
Visibly blurs fine lines and supports a more lifted, refined appearance with consistent use. Improves surface smoothness for a polished look.
Where you'll find it
Uses in Skincare & Cosmetics
Frequently found in eye creams, wrinkle serums, and plumping night creams. Also used in rich moisturizers targeting line-smoothing care.
Before you use it
Safety
Considered well tolerated for most users, with occasional mild irritation possible in sensitive skin. Patch testing is advisable; no specific regulatory limits commonly noted.