Palmitoyl Tripeptide-38

Palmitoyl tripeptide-38 is a modified signaling peptide with a palmitic anchor that improves its affinity for skin. Leave-on care includes it to promote smoother-looking texture and a sense of increased firmness with regular use.
Like this ingredient?

Snapshot

Overview
A peptide that helps blur fine lines and gives skin a firmer look.
Category
Anti-aging, Firming, Tone/Texture, Skin Conditioning
Type
Peptide

Ratings

Overall Rating

Good

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Palmitoyl Tripeptide-38 a Good Ingredient?

Rated Good because small in-vivo studies, often supplier-run, suggest visible wrinkle-smoothing, and its palmitoylated form improves stability and skin compatibility with a low irritation profile. It doesn't go higher because the supporting studies are mostly small and industry-sponsored rather than independent.

Skin Benefits

Visibly blurs fine lines and supports a more lifted, refined appearance with consistent use. Improves surface smoothness for a polished look.

Uses in Skincare & Cosmetics

Frequently found in eye creams, wrinkle serums, and plumping night creams. Also used in rich moisturizers targeting line-smoothing care.

Safety

Considered well tolerated for most users, with occasional mild irritation possible in sensitive skin. Patch testing is advisable; no specific regulatory limits commonly noted.