Snapshot
- Overview
- A lab-made peptide used to smooth and refine the look of skin.
- Category
- Skin Conditioning, Tone/Texture
- Type
- Peptide
Polypeptide-121
Polypeptide-121 is a biotechnology-derived synthetic polypeptide used in cosmetic formulations. It's included for skin conditioning and texture refinement, improving cosmetic feel and appearance, though consumer-facing evidence is still limited.
Like this ingredient?
Our take
Is Polypeptide-121 a Good Ingredient?
It's a promising conditioning peptide, but current cosmetic evidence is limited, so results may be modest, which keeps it at Fair; some users, especially very sensitive skin, could experience mild irritation.
What it does
Skin Benefits
May help skin feel smoother and look more refined; current cosmetic evidence is limited. Provides conditioning that can soften the look of uneven texture.
Where you'll find it
Uses in Skincare & Cosmetics
Used in peptide-focused serums, moisturizers, and eye creams aimed at improving surface feel. Also appears in leave-on treatments targeting a polished finish.
Before you use it
Safety
Generally considered low risk, yet peptides and their carriers can occasionally irritate reactive skin. Patch testing is prudent. Avoid use on compromised or freshly exfoliated skin if sensitivity occurs.
Products with Polypeptide-121
