Polyquaternium-51

Polyquaternium-51 is a biomimetic, water-soluble phospholipid polymer that forms a moisture-retentive film. It boosts water retention and comfort, and makes formulas gentler, which is why it shows up often in hydrating and soothing products.
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Snapshot

Overview
A hydrating polymer that keeps skin cushioned and comfortable.
Category
Hydration, Barrier Support, Sensitive Skin, Skin Conditioning
Type
Film Former

Ratings

Overall Rating

Great

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Polyquaternium-51 a Good Ingredient?

Rated Great because biomimetic hydration performance has been supported by in vivo and in-use studies showing improved moisture retention with a gentle profile. It is stable in water-based formulas and is typically well tolerated, making it appealing for sensitive routines.

Skin Benefits

Provides a lasting hydration feel and helps skin feel cushioned, reducing sensations of tightness. Often well-tolerated, making it appealing for easily irritated skin.

Uses in Skincare & Cosmetics

Featured in hydrating serums, moisturizers, and sheet masks to boost moisture comfort. Also used in eye creams and after-sun gels for a dewy, soothing finish.

Safety

Typically well tolerated with a low likelihood of irritation, including for dry or reactive skin types. As with any ingredient, rare sensitivity can occur; discontinue if irritation appears. No widely recognized regulatory limits for standard cosmetic use.