Polyquaternium-51 is a biomimetic, water-soluble phospholipid polymer that forms a moisture-retentive film. It boosts water retention and comfort, and makes formulas gentler, which is why it shows up often in hydrating and soothing products.
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Polyquaternium-51 a Good Ingredient?
Rated Great because biomimetic hydration performance has been supported by in vivo and in-use studies showing improved moisture retention with a gentle profile. It is stable in water-based formulas and is typically well tolerated, making it appealing for sensitive routines.
What it does
Skin Benefits
Provides a lasting hydration feel and helps skin feel cushioned, reducing sensations of tightness. Often well-tolerated, making it appealing for easily irritated skin.
Where you'll find it
Uses in Skincare & Cosmetics
Featured in hydrating serums, moisturizers, and sheet masks to boost moisture comfort. Also used in eye creams and after-sun gels for a dewy, soothing finish.
Before you use it
Safety
Typically well tolerated with a low likelihood of irritation, including for dry or reactive skin types. As with any ingredient, rare sensitivity can occur; discontinue if irritation appears. No widely recognized regulatory limits for standard cosmetic use.