Sh-Polypeptide-1 is a lab-engineered, water-soluble human-mimetic polypeptide. It's added to creams and serums to condition skin and improve the look of smoothness and firmness, but current support is modest and outcomes differ.
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Sh-Polypeptide-1 a Good Ingredient?
Good, because as a recombinant growth factor it may help promote skin renewal and improve the appearance of aging skin, and it's considered a premium ingredient found in advanced anti-aging formulations. The evidence behind it isn't extensive enough to reach Great, but the plausible mechanism and widespread premium use support Good.
What it does
Skin Benefits
Can promote a more supple feel and a smoother-looking surface, though evidence is limited, so improvements may be modest.
Where you'll find it
Uses in Skincare & Cosmetics
Used in emulsions like creams and lotions, as well as boost serums designed for daily use, and also appears in sheet masks for quick pick-me-ups.
Before you use it
Safety
Usually well tolerated at cosmetic use levels, though transient tingling or redness is possible. Perform a patch test if you have reactive skin. No specific regulatory limits are widely recognized for this ingredient.