Snapshot
- Overview
- A recombinant peptide used to condition skin and even out texture.
- Category
- Skin Conditioning, Anti-aging, Tone/Texture
- Type
- Peptide
Sh-Polypeptide-121
Sh-Polypeptide-121 is a recombinant, water-soluble cosmetic peptide. It's included to support skin conditioning and refine visible tone and texture; evidence is limited, and effectiveness depends on the formulation.
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Our take
Is Sh-Polypeptide-121 a Good Ingredient?
Clinical substantiation for this recombinant peptide is limited, and performance shifts with dose and delivery system, which is why it lands at Fair rather than higher. There's also a low but real risk of sensitivity reactions.
What it does
Skin Benefits
Over time it can promote a more supple feel and a more even-looking complexion, though results vary with concentration and how it's delivered in the formula.
Where you'll find it
Uses in Skincare & Cosmetics
It appears in serums and lotions, and occasionally in toners meant for layering into multi-step routines.
Before you use it
Safety
It's considered low risk for most users, though peptides and the preservatives that accompany them can irritate sensitive skin. Patch testing is advisable, and it isn't associated with phototoxic effects.
Products with Sh-Polypeptide-121
