Sh-Polypeptide-50

Sh-Polypeptide-50 is a laboratory-produced, water-soluble peptide made through biotechnology. It's added to condition skin and improve surface feel; data are preliminary, and performance varies with use level.
Like this ingredient?

Snapshot

Overview
A lab-made peptide that conditions skin for a smoother surface.
Category
Skin Conditioning, Anti-aging, Tone/Texture
Type
Peptide

Ratings

Overall Rating

Fair

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Sh-Polypeptide-50 a Good Ingredient?

The Fair rating reflects how preliminary the data still is: real-world efficacy is uncertain, and whatever benefit shows up is likely to be subtle and formula-dependent rather than reliable. Some users also report mild stinging or redness.

Skin Benefits

Used consistently, it aims to improve softness and give skin a velvety finish. The evidence for this is still preliminary, so any change is likely to be incremental.

Uses in Skincare & Cosmetics

It's used in moisturizers, leave-on masks, and makeup-priming lotions to smooth the skin before application.

Safety

There are no known ingredient-specific regulatory restrictions, and standard cosmetic use is considered low risk. Minor irritation can happen, particularly on compromised skin, so avoid applying it to broken or freshly exfoliated areas.