Sh-Polypeptide-9 is a lab-synthesized, water-soluble polypeptide patterned after human protein domains. Formulators use it to condition skin and support a firmer, more even look, but evidence remains limited and user experience is inconsistent.
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Sh-Polypeptide-9 a Good Ingredient?
The Fair rating comes down to thin research: there isn't much data behind this peptide, and outcomes are inconsistent enough that expectations should stay modest. It also carries a small risk of irritation or sensitization for sensitive users, which keeps it from scoring higher.
What it does
Skin Benefits
It may help skin look firmer and more refined, with some smoothing potential, though the supporting data are sparse and results vary from person to person.
Where you'll find it
Uses in Skincare & Cosmetics
It shows up mostly in concentrated serums and eye gels aimed at a tauter look, and occasionally in leave-on masks or moisturizers.
Before you use it
Safety
It's generally well tolerated in serums and creams, though occasional transient stinging can happen. Patch testing is a good idea for delicate or compromised skin. No specific regulatory limits are commonly cited for it.