Tetrapeptide-14 is a synthetic four-residue peptide optimized for water-based, leave-on skincare. It's selected for comfort-focused, sensitive-skin routines and general conditioning in light serums or gels, but strong independent support is still limited.
A peptide formulated to comfort sensitive, reactive-feeling skin.
Category
Soothing, Sensitive Skin, Skin Conditioning
Type
Peptide
Ratings
Overall Rating
Fair
Comedogenic Risk
None
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Tetrapeptide-14 a Good Ingredient?
It's Fair because soothing and anti-redness claims lack solid independent clinical backing, even though the peptide is formulated to be gentle. Even calming peptides like this one can occasionally trigger sensitivity.
What it does
Skin Benefits
Targets visible redness and signs of discomfort in reactive skin. Independent evidence remains limited.
Where you'll find it
Uses in Skincare & Cosmetics
Common in calming serums, lightweight moisturizers, and post-procedure sheet masks for easily irritated skin.
Before you use it
Safety
Usually well tolerated and suitable for sensitive-skin products, but patch testing is advisable if you're reactive. No commonly recognized cosmetic regulatory restrictions.