Tetrapeptide-2 is a synthetic four-amino-acid peptide compatible with aqueous, leave-on skincare. It's added to serums and creams for a firmer feel and a more refined look, but confirmation from solid independent studies is limited.
A synthetic peptide meant to give skin a firmer, more refined look.
Category
Anti-aging, Firming, Skin Conditioning
Type
Peptide
Ratings
Overall Rating
Fair
Comedogenic Risk
None
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Tetrapeptide-2 a Good Ingredient?
It's Fair because firmness and lifting claims rest on limited studies, so real-world effects may be subtle rather than dramatic. Minor irritation or redness can also occur in sensitive individuals.
What it does
Skin Benefits
May help skin feel firmer and improve the look of laxity, though available clinical support is modest.
Where you'll find it
Uses in Skincare & Cosmetics
Included in firming serums, neck creams, and eye lotions aimed at a more lifted, toned appearance.
Before you use it
Safety
Typically safe for routine use and not known to be photosensitizing. Patch test if prone to reactivity. No specific cosmetic regulatory limitations are commonly cited.