Tetrapeptide-4

Tetrapeptide-4 is a man-made peptide of four amino acids designed for easy inclusion in water-soluble skincare. It's used for skin conditioning and a smoother, more even look in primers and serums, though current independent evidence is limited.
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Snapshot

Overview
A peptide used to smooth texture and even out skin's appearance.
Category
Skin Conditioning, Anti-aging, Tone/Texture
Type
Peptide

Ratings

Overall Rating

Fair

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Tetrapeptide-4 a Good Ingredient?

It rates Fair since evidence for improving tone and texture is still early-stage, keeping expectations modest. There's also a slight risk of irritation or sensitization, particularly near the eyes.

Skin Benefits

May reduce the look of rough texture and promote a more uniform complexion. Research to date is preliminary.

Uses in Skincare & Cosmetics

Found in brightening serums, makeup primers, and hydrating gels to create a smoother canvas.

Safety

Generally low irritation potential and unlikely to clog pores, but discontinue if redness or stinging develops. No known special cosmetic regulatory restrictions.